Double-signal mode based on metal–organic framework coupled cascaded nucleic acid circuits for accurate and sensitive detection of serum circulating miRNAs
Susu Zhang, Shuling Xu, Xia Li, Rong-Na Ma, Guiguang Cheng, Qingwang Xue, Huaisheng Wang
Abstract
The tough challenges for the sensitive and accurate detection of circulating miRNAs (cmiRNAs) in the peripheral blood are low abundance, and high interference from environmental or background factors or other molecules. Here, we developed a double-signal mode based on metal-organic framework coupled cascaded nucleic acid circuits for the accurate and sensitive detection of serum circulating miRNAs.
Topics & Concepts
Nucleic acidSIGNAL (programming language)Electronic circuitmicroRNAChemistryBiological systemNanotechnologyComputer scienceElectronic engineeringMaterials scienceBiochemistryBiologyElectrical engineeringEngineeringProgramming languageGeneAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryMicroRNA in disease regulation