Mitochondrial Biology and the Identification of Biomarkers of Huntington’s Disease
Andreas Neueder, Michael Orth
Abstract
RNA levels or protein species can serve as biomarker, as could measures from biological systems or pathways in which Huntingtin plays an important role. Here we review the evidence for the involvement of mitochondrial biology in HD. The most consistent findings pertain to mitochondrial quality control, for example, fission/fusion. However, a convincing mitochondrial signature with biomarker potential is yet to emerge. This requires more research including in peripheral sources of human material, such as blood, or skeletal muscle.
Topics & Concepts
HuntingtinBiomarkerBiologyMitochondrionComputational biologyDiseaseMitochondrial fissionmitochondrial fusionIdentification (biology)Biomarker discoveryHuntington's diseaseBioinformaticsMitochondrial DNAMedicineGeneticsGeneProteomicsPathologyBotanyGenetic Neurodegenerative DiseasesMitochondrial Function and PathologyNeurological disorders and treatments