Role of microRNAs in Pressure Ulcer Immune Response, Pathogenesis, and Treatment
Stephen Niemiec, Amanda E. Louiselle, Kenneth W. Liechty, Carlos Zgheib
Abstract
Pressure ulcers are preventable, yet highly prevalent, chronic wounds that have significant patient morbidity and high healthcare costs. Like other chronic wounds, they are characterized by impaired wound healing due to dysregulated immune processes. This review will highlight key biochemical pathways in the pathogenesis of pressure injury and how this signaling leads to impaired wound healing. This review is the first to comprehensively describe the current literature on microRNA (miRNA, miR) regulation of pressure ulcer pathophysiology.
Topics & Concepts
PathogenesismicroRNAMedicineImmune systemWound healingBioinformaticsIntensive care medicinePathophysiologyMechanism (biology)ImmunologyChronic woundPathologyBiologyGeneBiochemistryPhilosophyEpistemologyWound Healing and TreatmentsPressure Ulcer Prevention and ManagementDiabetic Foot Ulcer Assessment and Management