Stiff extracellular matrix drives the differentiation of mesenchymal stem cells toward osteogenesis by the multiscale 3D genome reorganization
Jing Na, Chengzheng Tai, Ziyi Wang, Zhijie Yang, Xinyuan Chen, Jing Zhang, Lisha Zheng, Yubo Fan
Topics & Concepts
Extracellular matrixMesenchymal stem cellCell biologyRUNX2Cellular differentiationDownregulation and upregulationChromatinStem cellBiologyGene expressionGeneGeneticsGenomics and Chromatin DynamicsRNA Research and SplicingCellular Mechanics and Interactions