Lycopene regulates the mitochondrial unfolded protein response to prevent DEHP-induced cardiac mitochondrial damage in mice
Jia-Gen Cui, Yi Zhao, Hao Zhang, Xue‐Nan Li, Jin‐Long Li
Abstract
The study indicated that LYC regulated the mitochondrial unfolded protein response to prevent DEHP-induced cardiac mitochondrial damage. This study provides a feasible molecular mechanism for LYC to alleviate the cardiotoxicity induced by DEHP.
Topics & Concepts
PhthalateOxidative stressHeat shock proteinChemistryProteostasisMitochondrionMitochondrial ROSLycopeneHSP60AntioxidantALDH2BiochemistryHsp70Aldehyde dehydrogenaseGeneOrganic chemistryAntioxidant Activity and Oxidative StressVitamin C and Antioxidants ResearchCoenzyme Q10 studies and effects