Neocucurbols A–H, Phomactin Diterpene Derivatives from the Marine-Derived Fungus <i>Neocucurbitaria unguis-hominis</i> FS685
Jinhua Hu, Zhen‐Xing Zou, Yuchan Chen, Saini Li, Xiaoxia Gao, Zhaoming Liu, Yanlin Wang, Hongxin Liu, Weimin Zhang
Abstract
Neocucurbols A–D (1–4) are diterpene derivatives that possess a complex 6/6/5/5/6 polycyclic ring system with a characteristic tetrahedrofuran bridge ring skeleton. Neocucurbols E–H (5–8) are diterpenes that feature a 6/8/6 tricyclic ring system. Their structures were unambiguously determined by detailed spectroscopic analyses, X-ray diffractions studies, and ECD calculations. All compounds (1–8) were evaluated for in vitro antimicrobial and cytotoxic activities.
Topics & Concepts
DiterpeneStereochemistryRing (chemistry)PharmacognosyChemistryIn vitroBiological activityOrganic chemistryBiochemistryMicrobial Natural Products and BiosynthesisMarine Sponges and Natural ProductsSesquiterpenes and Asteraceae Studies