mTOR Signaling Network in Cell Biology and Human Disease
Jane Yu, Elena A. Goncharova
Abstract
The mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that regulates multiple processes, including gene transcription, protein synthesis, ribosome biogenesis, autophagy, cell metabolism, and cell growth [...].
Topics & Concepts
Ribosome biogenesisPI3K/AKT/mTOR pathwaymTORC2AutophagyRPTORCell biologymTORC1BiologyCell growthSerineKinaseBiogenesisSignal transductionAKT2CellMechanistic target of rapamycinAKT1RibosomeGenePhosphorylationBiochemistryRNAApoptosisPI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase SignalingPolyamine Metabolism and Applications