Using 4-vinylcyclohexene diepoxide as a model of menopause for cardiovascular disease
John P. Konhilas, Jessica N. Sanchez, Jessica A. Regan, Eleni Constantopoulos, Marissa A. Lopez‐Pier, Danielle K. Cannon, Rinku Skaria, Laurel McKee, Hao Chen, Yulia Lipovka, Dennis P. Pollow, Heddwen L. Brooks
Abstract
Before menopause, women are protected against cardiovascular disease (CVD) compared with age-matched men; this protection is gradually lost after menopause. We present the first evidence that demonstrates menopausal females are more susceptible to pathological cardiac remodeling while perimenopausal and cycling females are not. The VCD model permits appropriate examination of how increased susceptibility to the pathological process of cardiac remodeling accelerates from pre- to perimenopause to menopause.
Topics & Concepts
MenopauseDiseaseMedicineInternal medicineMenopause: Health Impacts and TreatmentsEstrogen and related hormone effectsFatty Acid Research and Health