Comparative genomics based exploration of xenobiotic degradation patterns in Glutamicibacter, Arthrobacter, and Pseudarthrobacter isolated from diverse ecological habitats
Nisha Ghimire, Byeollee Kim, So‐Ra Han, Tae‐Jin Oh
Abstract
species isolated from the environmental settings were identified as potential degraders of toluene, xylene, and phenanthrene. Notably, most strains contained pathways for azathioprine, capecitabine, and 5-fluorouridine pharmaceutical drug metabolism. Overall, our findings shed light on microbial metabolic diversity among 55 strains isolated from diverse sources and hint the importance of strict environmental monitoring. Further, for the application of the putative xenobiotic degrading strains, experimental validation is required in the future.
Topics & Concepts
XenobioticBiologyArthrobacterMicrobial ecologyGenomicsComputational biologyGeneticsGenomeGeneBacteriaBiochemistryEnzymePharmaceutical and Antibiotic Environmental ImpactsPharmacogenetics and Drug MetabolismMicrobial Natural Products and Biosynthesis