Activation of LXRs alleviates neuropathic pain-induced cognitive dysfunction by modulation of microglia polarization and synaptic plasticity via PI3K/AKT pathway
Siyi Han, Xiaoman Yuan, Fengtian Zhao, Anne Manyande, Feng Gao, Jie Wang, Wen Zhang, Xuebi Tian
Topics & Concepts
NeuroinflammationSNiMicrogliaPI3K/AKT/mTOR pathwaySynaptic plasticityNeuroscienceLiver X receptorMedicineNeuropathic painBrain-derived neurotrophic factorProtein kinase BNeurotrophic factorsInternal medicinePsychologyBiologySignal transductionReceptorInflammationCell biologyAcid hydrolysisNuclear receptorBiochemistryHydrolysisGeneTranscription factorPain Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration MechanismsGastrointestinal motility and disorders