Oncofetal protein IGF2BP1 regulates IQGAP3 expression to maintain stem cell potential in cancer
Khine Nyein Myint, Linda Shyue Huey Chuang, Yu Xuan Teh, Nur Astiana Mawan, Edward Jizhong Shi, Michelle Meng Huang Mok, Napat Nuttonmanit, Junichi Matsuo, Ying Li, Henry Yang, Atsushi Okabe, Atsushi Kaneda, Motomi Osato, Jimmy Bok Yan So, Wei Peng Yong, Patrick Tan, Khay Guan Yeoh, Yoshiaki Ito
Abstract
A-modified IQGAP3 transcripts. Downstream targets of IGF2BP1, namely SRF and FOXM1, also upregulate IQGAP3 expression. These multiple layers of IQGAP3 regulation, which may safeguard against inappropriate stem cell proliferation, present additional drug targets to inhibit IQGAP3-driven malignant growth.
Topics & Concepts
Downregulation and upregulationStem cellBiologyCarcinogenesisCancer stem cellCell biologyStem cell markerCancer researchCell growthCancerMolecular biologyGeneticsGeneRNA modifications and cancerRNA Research and SplicingCancer-related molecular mechanisms research