Novel kokumi peptides from yeast extract and their taste mechanism <i>via</i> an <i>in silico</i> study
Haofeng Lao, Jincui Chang, Haining Zhuang, Shiqing Song, Min Sun, Lingyun Yao, Huatian Wang, Qian Liu, Jian Xiong, Pei Li, Chuang Yu, Tao Feng
Abstract
van der Waals energy and polar solvation free energy, with key binding sites being Asp275, Ile416, Pro274, Arg66, Ala298, and Tyr218. This suggests that both peptides can activate the CaSR, thereby inducing kokumi activity. This study provides a theoretical foundation and reference for the screening and identification of kokumi peptides, successfully uncovering two novel kokumi peptides derived from yeast extract.
Topics & Concepts
In silicoElectronic tongueMechanism (biology)TasteYeastComputational biologyChemistryBiologyBiochemistryGeneEpistemologyPhilosophyBiochemical Analysis and Sensing TechniquesAdvanced Chemical Sensor TechnologiesOlfactory and Sensory Function Studies