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Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1

Binbin Cheng, Yichang Ren, Hao Cao, Jianjun Chen

2020European Journal of Medicinal Chemistry112 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryWestern blotResorcinolFlow cytometryPD-L1IC50ProteolysisPalladiumSmall moleculeImmune systemBiochemistryStereochemistryMolecular biologyCombinatorial chemistryIn vitroEnzymeImmunotherapyCatalysisBiologyImmunologyOrganic chemistryGeneProtein Degradation and InhibitorsCAR-T cell therapy researchMultiple Myeloma Research and Treatments
Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1 | Litcius