Tryptophan‐Kynurenine Pathway in COVID‐19‐Dependent Musculoskeletal Pathology: A Minireview
Sagar Vyavahare, Sandeep Kumar, Nicholas Cantu, Ravindra Kolhe, Wendy B. Bollag, Meghan E. McGee‐Lawrence, William Hill, Mark W. Hamrick, Carlos M. Isales, Sadanand Fulzele
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), affecting multiple organ systems, including the respiratory tract and lungs. Several studies have reported that the tryptophan-kynurenine pathway is altered in COVID-19 patients. The tryptophan-kynurenine pathway plays a vital role in regulating inflammation, metabolism, immune responses, and musculoskeletal system biology. In this minireview, we surmise the effects of the kynurenine pathway in COVID-19 patients and how this pathway might impact muscle and bone biology.