Diffusion and Relaxation Edited Proton NMR Spectroscopy of Plasma Reveals a High-Fidelity Supramolecular Biomarker Signature of SARS-CoV-2 Infection
Samantha Lodge, Philipp Nitschke, Torben Kimhofer, Julien Wist, Sze-How Bong, Ruey Leng Loo, Reika Masuda, Sofina Begum, Toby Richards, John C. Lindon, Wolfgang Bermel, Tony Reinsperger, Hartmut Schaefer, Manfred Spraul, Elaine Holmes, Jeremy K. Nicholson
Abstract
/GlycA are proposed as sensitive molecular markers for SARS-CoV-2 positivity that could effectively augment current COVID-19 diagnostics and may have value in functional assessment of the disease recovery process in patients with long-term symptoms.
Topics & Concepts
ChemistryBiomarkerGlycoproteinPhospholipidNuclear magnetic resonanceNuclear magnetic resonance spectroscopyAnalytical Chemistry (journal)BiochemistryChromatographyStereochemistryPhysicsMembraneMetabolomics and Mass Spectrometry StudiesInfectious Encephalopathies and EncephalitisLipid Membrane Structure and Behavior