Unveiling the molecular mechanism of pH-dependent interactions of human serum albumin with chemotherapeutic agent doxorubicin: A combined spectroscopic and constant-pH molecular dynamics study
Meiru Song, Wei Fu, Yichang Liu, Huiqiao Yao, Ke Zheng, Lin Liu, Jinping Xue, Peng Xu, Yayu Chen, Mingdong Huang, Jinyu Li
Topics & Concepts
Human serum albuminChemistryMolecular dynamicsDoxorubicinHydrogen bondBiophysicsMolecular modelRational designPlasma protein bindingBinding constantDrug deliveryCombinatorial chemistryStereochemistryBinding siteBiochemistryMoleculeComputational chemistryNanotechnologyOrganic chemistryMaterials scienceSurgeryMedicineChemotherapyBiologyProtein Interaction Studies and Fluorescence AnalysisNanoparticle-Based Drug DeliveryLanthanide and Transition Metal Complexes