SARS-CoV-2 Neutralization Resistance Mutations in Patient with HIV/AIDS, California, USA
Seth A. Hoffman, Cristina Costales, Malaya K. Sahoo, Srikanth Palanisamy, Fumiko Yamamoto, ChunHong Huang, Michelle Verghese, Daniel Solis, Mamdouh Sibai, Aruna Subramanian, Lucy S. Tompkins, Philip Grant, Robert W. Shafer, Benjamin A. Pinsky
Abstract
We report persistent severe acute respiratory syndrome coronavirus 2 infection in a patient with HIV/AIDS; the virus developed spike N terminal domain and receptor binding domain neutralization resistance mutations. Our findings suggest that immunocompromised patients can harbor emerging variants of severe acute respiratory syndrome coronavirus 2.
Topics & Concepts
NeutralizationVirologyCoronavirusMedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirusHuman immunodeficiency virus (HIV)Respiratory systemMutationBetacoronavirusImmunologyCoronavirus disease 2019 (COVID-19)BiologyGeneInternal medicineGeneticsInfectious disease (medical specialty)DiseaseSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesSARS-CoV-2 detection and testing