Lentivirus-mediated IL-10-expressing Bone Marrow Mesenchymal Stem Cells promote corneal allograft survival <i>via</i> upregulating lncRNA 003946 in a rat model of corneal allograft rejection
Xiaoxiao Lu, Yusha Ru, Chenchen Chu, Ying Lv, Yichen Gao, Zhe Jia, Yue Huang, Yan Zhang, Shaozhen Zhao
Abstract
macrophages. LncRNA, for the first time, is integrated into an IL-10-BM-MSC-driven immunomodulatory axis against the immune rejection to corneal allograft.
Topics & Concepts
Mesenchymal stem cellBone marrowLentivirusStem cellDownregulation and upregulationMedicineImmunologyPathologyBiologyCell biologyHuman immunodeficiency virus (HIV)GeneViral diseaseBiochemistryCancer-related molecular mechanisms researchMesenchymal stem cell researchRNA regulation and disease