Endometrial CD56+ natural killer cells in women with recurrent implantation failure: An immunohistochemical study
Gulchin Babayeva, Yunus Emre Purut, Burak Giray, Pembe Oltulu, Rabia Alakuş, Mehmet Cengiz Çolakoğlu
Abstract
OBJECTIVE: Implantation failure is a multifactorial problem of reproductive medicine. However, the mechanism of this process is still not fully understood. There is increasing evidence that these cases of recurrent implantation failure might have an immunologic background. Uterine natural killer (NK) cells provide immune-modulation at the interface between maternal decidua and the trophoblast. The aim of this study to evaluate whether there was a significant difference in the number of endometrial CD56+ NK between women with a history of recurrent implantation failure and women who had a live birth. MATERIALS AND METHODS: day of the menstrual cycle. RESULTS: in the control group. There was a statistically significant difference between the two groups (p=0.003). CONCLUSION: Implantation failure is a multifactorial problem of reproductive medicine. The results of our study suggest that uterine NK play a role in the progress of normal pregnancy and reduced uterine NK cell numbers were associated with implantation failure.