A hepatocyte-targeting fluorescent probe for imaging isoniazid-induced hydrazine in HepG2 cells and zebrafish
Zhenbo Guo, Mei Wang, Xueyan Li, Xu Jia, Xiaoli Wang, Pingzhu Zhang, Chao Wei, Xiaoliu Li
Abstract
A novel hepatocyte-targeting fluorescent N<sub>2</sub>H<sub>4</sub> probe was first prepared. The probe can be used to image N<sub>2</sub>H<sub>4</sub> produced by the hydrolysis of isoniazid in HepG2 cells and the liver of zebrafish <italic>in situ</italic>.
Topics & Concepts
ZebrafishHepatocyteHydrazine (antidepressant)IsoniazidFluorescenceChemistryHydrolysisMolecular biologyBiochemistryIn vitroBiologyPathologyMedicineGenePhysicsOpticsTuberculosisSulfur Compounds in BiologyMolecular Sensors and Ion DetectionDrug Transport and Resistance Mechanisms