TOX is expressed by exhausted and polyfunctional human effector memory CD8 <sup>+</sup> T cells
Takuya Sekine, André Perez‐Potti, Son Nguyen, Jean‐Baptiste Gorin, Vincent H. Wu, Emma Gostick, Sian Llewellyn‐Lacey, Quirin Hammer, Sara Falck‐Jones, Sindhu Vangeti, Meng Yu, Anna Smed‐Sörensen, Ahmed Gaballa, Michael Uhlin, Johan K. Sandberg, Christian Brander, Piotr Nowak, Paul Goepfert, David A. Price, Michael R. Betts, Marcus Buggert
Abstract
The transcription factor TOX is not exclusively linked to T cell exhaustion (see related Focus by Utzschneider and Kallies).
Topics & Concepts
EffectorTranscription factorCD8BiologyImmunologyCell biologyGeneticsGeneImmune systemImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses