Activation of hypoxia-sensing pathways promotes renal ischemic preconditioning following myocardial infarction
Andrew S. Terker, Kensuke Sasaki, Juan Pablo Arroyo, Aolei Niu, Suwan Wang, Xiaofeng Fan, Yahua Zhang, Sochinweichi Nwosisi, Ming‐Zhi Zhang, Raymond C. Harris
Abstract
Experimental myocardial infarction (MI) protects from subsequent ischemic acute kidney injury but worsens chronic kidney injury. Observed protection from ischemic acute kidney injury after MI was accompanied by chronic kidney hypoxia and increased renal abundance of hypoxia-inducible transcripts. These data support the idea that MI confers protection from renal ischemic injury via chronic renal hypoxia and activation of downstream hypoxia-inducible signaling pathways.
Topics & Concepts
Hypoxia (environmental)Ischemic preconditioningMyocardial infarctionCardiologyInternal medicineMedicineIschemiaChemistryOxygenOrganic chemistryCardiac Ischemia and ReperfusionCardiac Arrest and ResuscitationCardiovascular Function and Risk Factors