Effects of drug-drug interactions and CYP3A4 variants on alectinib metabolism
Yanan Liu, Jie Chen, Jing Wang, Qingqing Li, Guoxin Hu, Jianping Cai, Guanyang Lin, Ren-ai Xu
Topics & Concepts
CYP3A4MicrosomeChemistryPharmacologyMetabolitePharmacokineticsAlectinibDrug metabolismIn vivoDrug interactionDrugMetabolismIC50Non-competitive inhibitionHigh-performance liquid chromatographyActive metaboliteIn vitroCytochrome P450BiochemistryChromatographyEnzymeInternal medicineBiologyMedicineBiotechnologyCrizotinibPleural effusionMalignant pleural effusionPharmacogenetics and Drug MetabolismPI3K/AKT/mTOR signaling in cancerDrug Transport and Resistance Mechanisms