ZnO-based multifunctional nanocomposites to inhibit progression and metastasis of melanoma by eliciting antitumor immunity via immunogenic cell death
Yamin Zhang, Guo Chen, Liping Liu, Jian Xu, Hao Jiang, Danqi Li, Jiajia Lan, Jun Li, Jing Yang, Qiming Tu, Xiaoyan Sun, Mahin Alamgir, Xiang Chen, Guanxin Shen, Jintao Zhu, Juan Tao
Abstract
This study highlights the novel mechanism of ZnO-triggered anti-tumor immunity via inducing ICD. Additionally, we shed light on the multifunctionality of nanocomposites in delivering localized skin tumor therapy as well as inhibiting metastatic growth, which holds great promise in clinical applications.
Topics & Concepts
Immunogenic cell deathCancer researchImmunityMetastasisMelanomaProgrammed cell deathChemistryImmune systemMedicineCancerImmunotherapyApoptosisImmunologyInternal medicineBiochemistryNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisImmune cells in cancer