Mechanism and stereoselectivity in metal and enzyme catalyzed carbene insertion into X–H and C(sp<sup>2</sup>)–H bonds
Reena Balhara, Ritwika Chatterjee, Garima Jindal
Abstract
This review provides a mechanistic overview of asymmetric Fe, Cu, Pd, Rh, Au and heme-based enzymes catalyzed carbene insertion reactions to construct C–X (X = O, N, S, etc. ) and C–C bonds, focusing on the stereochemical models.
Topics & Concepts
CarbeneStereoselectivityInsertion reactionChemistryStereochemistryMetalCatalysisEnzymeOrganic chemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions