Characterisation of ST25 NDM-1-producing Acinetobacter spp. strains leading the increase in NDM-1 emergence in Argentina
Deja Rodgers, Fernando Pasterán, Manuel Calderón, Sara Jaber, Germán M. Traglia, Ezequiel Albornoz, Alejandra Corso, Alejandro J. Vila, Robert A. Bonomo, Mark D. Adams, María Soledad
Abstract
Carbapenem-resistant Acinetobacter baumannii are recognised by the US Centers for Disease Control and Prevention (CDC) as an urgent threat [1]. The most prevalent mechanism of carbapenem resistance in Acinetobacter spp. is due to the presence of carbapenem-hydrolysing class D β-lactamases, with OXA-23 being the most common. The observed dispersion of blaOXA-23 is attributed in part to the spread of successful A. baumannii global clones such as GC1 and GC2 [2]. However, in the most recent years an increased emergence of blaNDM-1-harbouring Acinetobacter spp. isolates has been reported