Synthesis, characterization and biological evaluation of dipicolylamine sulfonamide derivatized platinum complexes as potential anticancer agents
Nadini Thushara, Taniya Darshani, Sameera R. Samarakoon, Inoka C. Perera, Frank R. Fronczek, W. M. C. Sameera, Theshini Perera
Abstract
Three new Pt complexes, [PtCl<sub>2</sub>(N(SO<sub>2</sub>(2-nap))dpa)], [PtCl<sub>2</sub>(N(SO<sub>2</sub>(1-nap))dpa)] and [PtCl<sub>2</sub>(N(SO<sub>2</sub>pip)dpa)], containing a rare 8-membered ring were synthesized in good yield and high purity by utilizing ligands which contain a dipicolylamine moiety.
Topics & Concepts
ChemistryNapDenticityMoietyYield (engineering)Ring (chemistry)Ligand (biochemistry)StereochemistryPlatinumCombinatorial chemistryMedicinal chemistryMetalOrganic chemistryReceptorBiochemistryMaterials scienceCatalysisMetallurgyNeuroscienceBiologyMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsMagnetism in coordination complexes