Venetoclax in association with decitabine as effective bridge to transplant in a case of relapsed early T‐cell lymphoblastic leukemia
Elisabetta Zappone, Emanuele Cencini, Marzia Defina, Anna Sicuranza, Alessandro Gozzetti, Sara Ciofini, Donatella Raspadori, Bianca Mecacci, Monica Bocchia
Abstract
A case of an early-relapsed high-risk T-ALL with high BCL-2 expression on leukemic blasts was successfully treated with decitabine and venetoclax, achieving a CR. We suggest decitabine and venetoclax should be synergistic in BCL2-positive ALL.
Topics & Concepts
DecitabineVenetoclaxMedicineLymphoblastic LeukemiaOncologyLeukemiaInternal medicineComplete remissionChemotherapyChronic lymphocytic leukemiaGeneticsDNA methylationBiologyGene expressionGeneAcute Lymphoblastic Leukemia researchChronic Myeloid Leukemia TreatmentsChronic Lymphocytic Leukemia Research