Design, synthesis, and anti-proliferative evaluation of 1<i>H</i>-1,2,3-triazole grafted tetrahydro-β-carboline-chalcone/ferrocenylchalcone conjugates in estrogen responsive and triple negative breast cancer cells
Bharvi Sharma, Liang Gu, Ruvesh Pascal Pillay, Nosipho Cele, Paul Awolade, Parvesh Singh, Mandeep Kaur, Vipan Kumar
Abstract
A series of 1<italic>H</italic>-1,2,3 triazole grafted tetrahydro-β-carboline-chalcone/ferrocenylchalcone conjugates were synthesized and <italic>in vitro</italic> evaluated against estrogen responsive (MCF-7) and triple negative (MDA-MB-231) breast cancer cells.
Topics & Concepts
ChemistryChalconeTriple-negative breast cancerConjugateTriazoleStereochemistryCombinatorial chemistryBreast cancerCancerOrganic chemistryInternal medicineMathematicsMedicineMathematical analysisSynthesis and Biological EvaluationSynthesis and bioactivity of alkaloidsFerrocene Chemistry and Applications