The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4
Xingguang Cai, Sacha Javor, Bee‐Ha Gan, Thilo Köhler, Jean‐Louis Reymond
Abstract
pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar effect occurs with polymyxin B and might be general for polycationic antimicrobials.
Topics & Concepts
DendrimerPolymyxinPolymyxin BKlebsiella pneumoniaePeptideAntimicrobialChemistryAntibacterial activityMicrobiologyBacteriaAntibioticsBiochemistryEscherichia coliBiologyOrganic chemistryGeneGeneticsDendrimers and Hyperbranched PolymersAntimicrobial Peptides and ActivitiesRNA Interference and Gene Delivery