Design and Computational Analysis of an MMP9 Inhibitor in Hypoxia-Induced Glioblastoma Multiforme
Smita Kumari, Pravir Kumar
Abstract
-1-benzopyran, and 4'-hydroxy-7-methoxyflavan, to inhibit MMP9, a novel hypoxia gene signature that could serve as a promising predictor in various clinical applications, including GBM diagnosis, prognosis, and targeted therapy.
Topics & Concepts
MMP9Hypoxia (environmental)GlioblastomaCancer researchTIMP1GeneBiologyComputational biologyBioinformaticsChemistryDownregulation and upregulationGene expressionGeneticsOrganic chemistryOxygenCancer, Hypoxia, and MetabolismUbiquitin and proteasome pathwaysRNA modifications and cancer