Mn(<scp>ii</scp>)-Conjugated silica nanoparticles as potential MRI probes
Daniela Lalli, Giuseppe Ferrauto, Enzo Terreno, Fabio Carniato, Mauro Botta
Abstract
A novel Mn( ii )-based nanoprobe was synthesized as a high contrast enhancing agent for magnetic resonance imaging. The sample shows high relaxivity at the clinical fields and in vivo studies on healthy mice demonstrated its efficacy as T 1w -MRI probe.
Topics & Concepts
Materials scienceChelationConjugated systemNanoparticleMagnetic resonance imagingIn vivoMRI contrast agentParamagnetismNanotechnologyNuclear magnetic resonanceBiophysicsPolymerRadiologyMedicineBiologyBiotechnologyPhysicsComposite materialQuantum mechanicsMetallurgyLanthanide and Transition Metal ComplexesAdvanced MRI Techniques and ApplicationsNanoparticle-Based Drug Delivery