Design concepts for DNA-encoded library synthesis
Y. Zhang, Matthew Clark
Abstract
An approach of building block (BB) inclusivity and atom efficient library schemes deliver the quality and diversity of DNA-encoded libraries best suited for small molecule drug discovery. In this Perspective, we offer key learnings in DEL design from a decade's worth of DEL-driven screening.
Topics & Concepts
ChemistryDNAComputational biologyCombinatorial chemistryChemical synthesisStereochemistryBiochemistryIn vitroBiologyChemical Synthesis and AnalysisClick Chemistry and ApplicationsAdvanced biosensing and bioanalysis techniques