Novel Azine Linked Hybrids of 2-Indolinone and Thiazolodinone Scaffolds as CDK2 Inhibitors with Potential Anticancer Activity: In Silico Design, Synthesis, Biological, Molecular Dynamics and Binding Free Energy Studies
Wesam S. Qayed, Mostafa A. Hassan, Wael M. El‐Sayed, José Rogério A. Silva, Tarek Aboul‐Fadl
Topics & Concepts
ChemistryADMEIn silicoSunitinibDocking (animal)Small moleculeCombinatorial chemistryStereochemistryBiological activityBiochemistryIn vitroMedicineNursingGeneRenal cell carcinomaOncologySynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activityClick Chemistry and Applications