Rpgrip1l controls ciliary gating by ensuring the proper amount of Cep290 at the vertebrate transition zone
Antonia Wiegering, Renate Dildrop, Christine Vesque, Hemant Khanna, Sylvie Schneider‐Maunoury, Christoph Gerhardt
Abstract
The study provided by Wiegering et al. investigates molecular mechanisms underlying ciliary entry and exit of proteins. It demonstrates that Rpgrip1l governs ciliary gating by controlling the amount of Cep290 at the vertebrate transition zone.
Topics & Concepts
BiologyVertebrateCell biologyGatingCiliumAnatomyZoologyBiophysicsGeneticsGeneGenetic and Kidney Cyst DiseasesRetinal Development and DisordersFetal and Pediatric Neurological Disorders