Stp1 Loss of Function Promotes β-Lactam Resistance in Staphylococcus aureus That Is Independent of Classical Genes
Aditi Chatterjee, Raymond Poon, Som S. Chatterjee
Abstract
β-Lactam resistance in Staphylococcus aureus limits treatment options. Stp1 and Stk1, a serine-threonine phosphatase and kinase, respectively, mediate serine-threonine kinase (STK) signaling. Loss-of-function point mutations in stp1 were detected among laboratory-passaged β-lactam-resistant S. aureus strains lacking mecA and blaZ , the major determinants of β-lactam resistance in the bacteria.
Topics & Concepts
Staphylococcus aureusSerineThreonineMicrobiologyBiologyPhosphataseGenePoint mutationBacteriaGeneticsPhosphorylationMutationAntimicrobial Resistance in StaphylococcusMicrobial Natural Products and BiosynthesisPlant-Microbe Interactions and Immunity