A quality by design approach for optimization of Lecithin/Span® 80 based nanoemulsions loaded with hydrophobic drugs
Daniel Andrés Real, Stefan Hoffmann, Darío Leonardi, Francisco M. Goycoolea, Claudio J. Salomón
Topics & Concepts
Factorial experimentLecithinFractional factorial designPlackett–Burman designChromatographyChemistryQuality by DesignCentral composite designMathematicsResponse surface methodologyParticle sizeStatisticsPhysical chemistryDrug Solubulity and Delivery SystemsAdvanced Drug Delivery SystemsSurfactants and Colloidal Systems