An Insight into Aging, Senescence, and Their Impacts on Wound Healing
Rex Jeya Rajkumar Samdavid Thanapaul, Maria Shvedova, Grace Haeun Shin, Danny S. Roh
Abstract
Cellular senescence has been found to have beneficial roles in development, tissue regeneration, and wound healing. However, in aging senescence increases, and the ability to properly repair and heal wounds significantly declines across multiple tissues. This age-related accumulation of senescent cells may cause loss of tissue homeostasis leading to dysregulation of normal and timely wound healing processes. The delays in wound healing of aging have widespread clinical and economic impacts, thus novel strategies to improve wound healing in aging are needed and targeting senescence may be a promising area.
Topics & Concepts
SenescenceWound healingCellular senescenceRegeneration (biology)MedicineTissue repairBiologyCell biologyImmunologyPhenotypeBiochemistryGeneTelomeres, Telomerase, and SenescenceWound Healing and TreatmentsSkin Protection and Aging