Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals
Donald A. Lamb, Johnathon H. Moore, Paulo H. C. Mesquita, Morgan A. Smith, Christopher G. Vann, Shelby C. Osburn, Carlton D. Fox, Hector L. Lopez, Tim N. Ziegenfuss, Kevin W. Huggins, Michael D. Goodlett, Andrew D. Frugé, Andreas N. Kavazis, Kaelin C. Young, Michael D. Roberts
Abstract
, NADH, and global SIRT activity are positively affected by resistance training in middle-aged, untrained individuals. Whether these adaptations facilitated mitochondrial biogenesis remains to be determined.
Topics & Concepts
SirtuinNAD+ kinaseResistance trainingOverweightSirtuin 1Internal medicineEndocrinologyGerontologyMedicinePsychologyPhysiologyBiologyBiochemistryEnzymeGeneObesityDownregulation and upregulationAdipose Tissue and MetabolismSirtuins and Resveratrol in MedicineExercise and Physiological Responses