Design, synthesis, and biological evaluation of novel artemisinin-based HDAC inhibitors with antitumor and antimalarial activities
Jin He, Youyou He, Yunan Qian, Shanmei Du, R. Li-jiun Sun, Yujiao Liu, Jing Yu, Yi Ding, Siyuan Zhou, Lubin Jiang, Shengzheng Wang
Topics & Concepts
ArtemisininChemistryAntimalarial AgentPharmacologyPlasmodium falciparumHistone deacetylaseCombinatorial chemistryMalariaComputational biologyBiochemistryHistoneDNAImmunologyMedicineBiologyHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsSignaling Pathways in Disease