Sirtuin 3 Downregulation in <i>Mycobacterium tuberculosis</i> -Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death
Lorissa J. Smulan, Núria Martínez, Michael C Kiritsy, Chido Loveness Kativhu, Kelly Cavallo, Christopher M. Sassetti, Amit Singhal, Heinz G. Remold, Hardy Kornfeld
Abstract
Tuberculosis, the disease caused by the bacterium M. tuberculosis , remains one of the top 10 causes of death worldwide. Macrophages, the first cells to encounter M. tuberculosis and critical for defense against infection, are hijacked by M. tuberculosis as a protected growth niche. M. tuberculosis -infected macrophages undergo metabolic reprogramming where key mitochondrial pathways are modulated, but the mechanisms driving this metabolic shift is unknown.
Topics & Concepts
SIRT3SirtuinBiologyCell biologyMycobacterium tuberculosisMitochondrionInflammationMicrobiologyNAD+ kinaseTuberculosisImmunologyBiochemistryEnzymeMedicinePathologySirtuins and Resveratrol in MedicineAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolism