Divergent Total Syntheses of Yaequinolone-Related Natural Products by Late-Stage C–H Olefination
Wen‐Liang Jia, Sabela Vega Ces, M. Ángeles Fernández‐Ibáñez
Abstract
)-ones, core structures of this family of natural products. A robust synthetic methodology to construct the core structures has been established, and the C-H olefination reaction has been carried out with synthetically useful yields and high levels of site-selectivity under mild reaction conditions in the presence of a Pd/S,O-ligand catalyst.
Topics & Concepts
ChemistryTotal synthesisNatural (archaeology)CatalysisCombinatorial chemistrySelectivityOrganic chemistryStereochemistryArchaeologyHistoryCatalytic C–H Functionalization MethodsSynthetic Organic Chemistry MethodsSynthesis and Catalytic Reactions