MBZM-N-IBT, a Novel Small Molecule, Restricts Chikungunya Virus Infection by Targeting nsP2 Protease Activity <i>In Vitro</i> , <i>In Vivo</i> , and <i>Ex Vivo</i>
Saikat De, Soumyajit Ghosh, Supriya Suman Keshry, Chandan Mahish, Chinmayee Mohapatra, Ankeeta Guru, Prabhudutta Mamidi, Ankita Datey, Sweta Smita Pani, D. Vasudevan, Tushar Kant Beuria, Subhasis Chattopadhyay, Subhasis Chattopadhyay, Bharat Bhusan Subudhi, Soma Chattopadhyay, Soma Chattopadhyay
Abstract
The increase in disease incidences and persistent Chikungunya virus (CHIKV)-induced arthritis have been a huge burden on public health globally. In the absence of specific antivirals or vaccines, it is essential to continue efforts to develop effective anti-CHIKV strategies.
Topics & Concepts
ChikungunyaIn vivoEx vivoIn vitroVirusVero cellPeripheral blood mononuclear cellBiologyTLR7VirologyArthritisImmunologyProteaseDownregulation and upregulationPharmacologyEnzymeImmune systemBiochemistryToll-like receptorGeneBiotechnologyInnate immune systemMosquito-borne diseases and controlHIV Research and Treatmentinterferon and immune responses