Cyclin D1 mediated by the nuclear translocation of nuclear factor kappa B exerts an oncogenic role in lung cancer
Xin Wang, Xiaoping Liu, Yanxia Yang, Daowen Yang
Abstract
. Our data revealed that NF-κB/CCND1/PI3K/AKT axis could act as a prospective diagnostic biomarker and a therapeutic option for lung cancer.
Topics & Concepts
Cyclin D1Cancer researchLung cancerPI3K/AKT/mTOR pathwayProtein kinase BCyclin DCancerCell cycleCancer cellBiologySignal transductionMedicinePathologyInternal medicineCell biologyCancer-related Molecular PathwaysCancer Mechanisms and TherapyRNA modifications and cancer