A Bi<sub>2</sub>S<sub>3</sub>-embedded gellan gum hydrogel for localized tumor photothermal/antiangiogenic therapy
Yingjiao Wu, Yuqing Liang, Yandi Liu, Yijun Hao, Na Tao, Juan Li, Xiaoyi Sun, Ming Zhou, You‐Nian Liu
Abstract
), integrated with real-time monitoring drug retention and tunable therapeutic functions. After the incorporation of sorafenib (SF), the hydrogel shows a sustained release of SF over 15 days. A tumor suppression rate of 98.2% is shown at day 22 postinjection in the mice received the combined treatments of photothermal/antiangiogenic therapy. In contrast, tumor growth and recurrence are observed in the single treatment. Our work presents a new strategy to construct a multifunctional hydrogel platform for a safe and precise antitumor therapy.
Topics & Concepts
Gellan gumPhotothermal therapyMaterials scienceNanodotBiomedical engineeringNanotechnologyChemistryMedicineFood scienceNanoplatforms for cancer theranosticsExtracellular vesicles in diseaseAngiogenesis and VEGF in Cancer