Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation
L. Alexander Liggett, Matthew D. Galbraith, Keith P. Smith, Kelly D. Sullivan, Ross E. Granrath, Belinda A Enriquez-Estrada, Kohl T. Kinning, Jessica R. Shaw, Angela L. Rachubinski, Joaquı́n M. Espinosa, James DeGregori
Abstract
Key Points Children with Down syndrome develop early signs of clonal evolution that resemble traditional clonal hematopoiesis. Children with trisomy 21 who exhibit clonal hematopoiesis display cytokine and gene expression profiles indicative of disrupted immunity.
Topics & Concepts
HaematopoiesisTrisomyImmune dysregulationBiologyImmunologySomatic evolution in cancerImmune systemImmunityCytokineDown syndromeGeneGeneticsStem cellAcute Myeloid Leukemia ResearchImmunodeficiency and Autoimmune DisordersNeutrophil, Myeloperoxidase and Oxidative Mechanisms