Microwave-assisted copper(<scp>i</scp>) catalyzed A<sup>3</sup> cascade coupling of imidazo[1,2-<i>a</i>]pyridines <i>via</i> C–H bond functionalization as selective COX-2 inhibitors and antioxidants, and <i>in silico</i> studies
Aravind R. Nesaragi, Ravindra R. Kamble, Swati R. Hoolageri, Shruti Dixit, Shrinivas D. Joshi, Shyamkumar Vootla, Vijay Kumbar
Abstract
A proficient copper( i ) catalyzed one pot synthetic protocol has been established to synthesize medicinally essential substituted imidazo[1,2- a ]pyridines via C–H bond amination followed by acetylene incorporation under microwave irradiation.
Topics & Concepts
ChemistryAminationSurface modificationCatalysisAcetyleneCopperCascadeMicrowave irradiationCombinatorial chemistryCascade reactionMedicinal chemistryStereochemistryOrganic chemistryPhysical chemistryChromatographyCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsClick Chemistry and Applications