Improvement of the antimicrobial potency, pharmacokinetic and pharmacodynamic properties of albicidin by incorporation of nitrogen atoms
Lieby Zborovsky, Leonardo Kleebauer, Maria Seidel, Arseni Kostenko, Leonard von Eckardstein, Frank O. Gombert, John B. Weston, Roderich D. Süßmuth
Abstract
infection model with FQ-resistant clinically relevant strains. These results qualify albicidins as active antibacterial substances with the potential to be developed as a drug for treatment of infections caused by Gram-negative and Gram-positive bacteria.
Topics & Concepts
PotencyPharmacodynamicsAntimicrobialPharmacokineticsNitrogenChemistryPharmacologyCombinatorial chemistryMedicineBiochemistryOrganic chemistryIn vitroPhenothiazines and Benzothiazines Synthesis and ActivitiesSynthesis and biological activityEssential Oils and Antimicrobial Activity