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Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

Kirk Brown, Jayaprakash K. Nair, Maja M. Janas, Yesseinia Angleró-Rodríguez, Lan Dang, Haiyan Peng, Christopher S. Theile, Elena Castellanos-Rizaldos, Christopher R. Brown, Donald J. Foster, Jeffrey C. Kurz, Jeffrey C. Allen, Rajanikanth J Maganti, Jing Li, Shigeo Matsuda, Matthew Stricos, Tyler Chickering, Michelle Jung, Kelly Wassarman, Jeff Rollins, Lauren Blair Woods, Alex Kelin, Dale C. Guenther, Melissa W. Mobley, John R. Petrulis, Robin McDougall, Timothy Racie, Jessica Bombardier, Diana Cha, Saket Agarwal, Lei Johnson, Yongfeng Jiang, Scott Lentini, Jason A. Gilbert, Tuyen Nguyen, Samantha Chigas, Sarah LeBlanc, Urjana Poreci, Anne Kasper, Arlin B. Rogers, Saeho Chong, Wendell Davis, Jessica E. Sutherland, Adam Castoreno, Stuart Milstein, Mark K. Schlegel, Ivan Zlatev, Klaus Charissé, Mark Keating, Muthiah Manoharan, Kevin Fitzgerald, Jing‐Tao Wu, Martin A. Maier, Vasant Jadhav

2022Nature Biotechnology246 citationsDOI

Topics & Concepts

Small interfering RNARNA interferenceGene silencingGene knockdownPharmacologyBiologyNasal administrationSystemic administrationCellCentral nervous systemRNAMedicineNeuroscienceIn vivoGeneBiochemistryBiotechnologyRNA Interference and Gene DeliveryMicroRNA in disease regulationAdvanced biosensing and bioanalysis techniques
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates | Litcius