Intraparenchymal metastases as a cause for local recurrence of pancreatic cancer
Ashley Kiemen, Young Geun Choi, Alicia M. Braxton, Cristina Almagro Pérez, Sarah E. Graham, Mia P. Grahn, Neha Nanda, Nicholas J. Roberts, Laura D. Wood, Pei‐Hsun Wu, Ralph H. Hruban, Denis Wirtz
Abstract
Using CODA, a technique for three-dimensional reconstruction of large tissues, Kiemen et al. report observation of a microscopic focus of pancreatic cancer found in the vasculature of grossly normal human pancreas tissue resected adjacent to a large tumour. They use TP53 and SMAD4 staining to relate the small focus to the primary tumour. This report describes a represents a probable case of intraparenchymal metastasis of pancreatic cancer, revealing a probable cause of local recurrence. The authors have no conflicts of interest to disclose. The data presented in this study are available from the corresponding authors upon request. Video S1. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.